期刊
CANCER LETTERS
卷 185, 期 2, 页码 153-161出版社
ELSEVIER SCI IRELAND LTD
DOI: 10.1016/S0304-3835(02)00278-1
关键词
glioblastoma; cerivastatin; focal adhesion kinase; migration
类别
To investigate the biological effect of cerivastatin on glioblastoma cells, we exposed them to various concentrations of cerivastatin. Cerivastatin exhibited dual effects on glioblastoma cells in a dose-dependent manner. Immunofluorescence microscopy showed disruption of actin stress fibers and focal adhesion plaques even at nanomolar concentrations. Matrigel assay demonstrated marked inhibition of glioblastorna cell invasion. Immunoblot analysis using a phosphospecific antibody against focal adhesion kinase (FAK) showed that inhibition of migration was associated with the down-regulation of tyrosine phosphorylation of FAK. Our data suggest that cerivastatin may be beneficial for combination therapy with conventional anticancer drugs by inhibiting the invasion of glioblastoma. (C) 2002 Elsevier Science Ireland Ltd. All rights reserved.
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