graphic The synthesis of a simplified thioglycosidic analogue (2) of mycothiol (1) is described. Evaluation of 2 against mycothiol S-conjugate amidase from Mycobacterium tuberculosis reveals good specific activity (7500 nmol min(-1) mg-protein(-1), vs 14 200 for 1), indicating that 2 can serve as a starting point for antitubercular drug design.
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