期刊
MOLECULAR AND CELLULAR ENDOCRINOLOGY
卷 197, 期 1-2, 页码 117-125出版社
ELSEVIER IRELAND LTD
DOI: 10.1016/S0303-7207(02)00285-X
关键词
Mustela putorius furo; adrenal gland; gonadotrophic hormones; cortisol/creatinine ratio; androstenedione; 17 alpha-hydroxyprogesterone
Four studies were performed to test the hypothesis that gonadotrophic hormones, and particularly luteinizing hormone (LH), play a role in the pathogenesis of hyperadrenocorticism in ferrets: (1) adrenal glands of ferrets with hyperadrenocorticism were studied immunohistochemically to detect LH-receptors (LH-R); (II) gonadotrophin-releasing hormone (GnRH) stimulation tests were performed in 10 neutered ferrets, with measurement of androstenedione, 17alpha-hydroxyprogesterone and cortisol as endpoints; (III) GnRH stimulation tests were performed in 15 ferrets of which 8 had hyperadrenocorticism, via puncture of the vena cava under anesthesia; and (IV) urinary corticoid/creatinine (C/C) ratios were measured at 2-week intervals for 1 year in the same ferrets as used in study II. Clear cells in hyperplastic or neoplastic adrenal glands of hyperadrenocorticoid ferrets stained positive with the LH-R antibody. Plasma androstenedione and 17alpha-hydroxyprogesterone concentrations increased after stimulation with GnRH in 7 out of 8 hyperadrenocorticoid ferrets but in only 1 out of 7 healthy ferrets. Hyperadrenocorticoid ferrets had elevated urinary C/C ratios during the breeding season. The observations support the hypothesis that gonadotrophic hormones play a role in the pathogenesis of hyperadrenocorticism in ferrets. This condition may be defined as a disease resulting from the expression of LH-R on sex steroid-producing adrenocortical cells. (C) 2002 Elsevier Science Ireland Ltd. All rights reserved.
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