期刊
ZEITSCHRIFT FUR GASTROENTEROLOGIE
卷 40, 期 12, 页码 983-990出版社
GEORG THIEME VERLAG KG
DOI: 10.1055/s-2002-36159
关键词
innate immunity; intestinal epithelium; host defense; mucosa; toll-like receptors; nods; apoptosis
资金
- NIDDK NIH HHS [DK41557, DK43351] Funding Source: Medline
The intestinal epithelium serves as an essential defensive barrier of the mucosal immune system that forms a bipolar interface between the diverse populations of microbes of the lumen and subjacent immune cells present in the lamina propria. Intestinal epithelial cells express various pattern recognition receptors poised to recognize microbial pathogen-associated molecular patterns as non-self'' and to rapidly initiate innate immune responses of survival and active defense strategies against lumenal pathogens. Current understanding of the variety of innate immune features present in intestinal epithelium to maintain homeostasis is summarized and the mechanisms through which dysregulation may play a central role in initiation and perpetuation of inflammatory bowel disease are discussed.
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