期刊
EUROPEAN NEUROPSYCHOPHARMACOLOGY
卷 12, 期 6, 页码 581-586出版社
ELSEVIER
DOI: 10.1016/S0924-977X(02)00107-4
关键词
neuroinflammation; positron emission tomography; [C-11](R)-PK11195
We briefly outline the rationale for employing positron emission tomography (PET), using the ligand [C-11](R)-PK11195, the binding site for which is highly expressed by activated microglia, in order (a) to detect in vivo neuroinflammatory changes occurring in a variety of brain diseases and at different disease stages and (b) to monitor the progression of neuroinflammation as a generic in vivo marker of 'disease activity'. The use of [C-11](R)-PK11195 PET is described as a systematic attempt at measuring the emerging phenomenology of tissue pathology itself-as opposed to measuring, for example, the loss of neuronal function or structure-and as a proof of principle for the clinical utility of imaging glial cells in vivo. (C) 2002 Elsevier Science B.V./ECNP All rights reserved.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据