期刊
MOLECULAR IMMUNOLOGY
卷 39, 期 9, 页码 499-508出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/S0161-5890(02)00206-7
关键词
VCAM-1signals; lymphocyte migration; matrix metalloproteinases; cytokine; actin
资金
- NHLBI NIH HHS [R01 HL068171, R01 HL068171-02, R01 HL68171, R01 HL068171-03, R01 HL068171-04, R01 HL068171-01] Funding Source: Medline
- NIAID NIH HHS [R01 AI040640-04, R29AI34585, R01AI40640, R01 AI040640-03] Funding Source: Medline
- NIA NIH HHS [R01 AG040640] Funding Source: Medline
Vascular cell adhesion molecule-1 (VCAM-1) regulates leukocyte migration from the blood into tissues. VCAM-1 expression is induced on endothelial cells during inflammatory bowel disease, atherosclerosis, allograft rejection, infection, and asthmatic responses. During these responses, VCAM-1 forms a scaffold for leukocyte migration. VCAM-1 also activates signals within endothelial cells resulting in the opening of an endothelial cell gate through which leukocytes migrate. Immediately following this migration, the endothelial cell-endothelial cell contact is re-established. VCAM-1 outside-in signals are mediated by NADPH oxidase production of reactive oxygen species and subsequently activation of matrix metalloproteinases. These signals are required for endothelial cell shape changes and leukocyte migration. In addition, VCAM-1-activated signals in endothelial cells are regulated by cytokines indicating that it is important to consider both endothelial cell adhesion molecule expression and function during inflammatory processes. (C) 2002 Elsevier Science Ltd. All rights reserved.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据