期刊
EXPERT OPINION ON BIOLOGICAL THERAPY
卷 2, 期 8, 页码 805-818出版社
TAYLOR & FRANCIS LTD
DOI: 10.1517/14712598.2.8.805
关键词
arteriogenesis; gene therapy; growth factors; ischaemia; neovascularisation; revascularisation; therapeutic angiogenesis; vasculogenesis
资金
- NIGMS NIH HHS [T32 GM145304] Funding Source: Medline
Neovascularisation is :a promising alternative therapeutic approach to reestablish blood flow in ischaemic tissues of patients suffering from coronary artery or peripheral artery disease. Often, these patients are not suitable candidates for current revascularisation procedures such as coronary angioplasty or bypass surgery. Several strategies are presently under investigation to induce vascularisation by stimulating the body's natural processes of vasculogenesis, angiogenesis and arteriogenesis. These strategies involve transplantation of various cell types into the ischaemic site and the delivery of recombinant angiogenic agents through direct protein administration or gene transfer. We will examine the basic approaches for these neovacularisation strategies and their therapeutic potential as demonstrated in animal models and human trials to date.
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