期刊
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
卷 37, 期 12, 页码 973-978出版社
ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER
DOI: 10.1016/S0223-5234(02)01421-6
关键词
2-trifluoromethylbenzimidazoles; 2-pentafluoroethylbenzimidazoles; antiprotozoal activity; anticancer activity
The synthesis of several halogenated benzimidazoles substituted in position 2 with trifluoromethyl, pentafluoroethyl and 2-thioethylaminodimethyl group is reported. Antiprotozoal and anticancer activity of series of newly synthesized and previously obtained compounds was studied. All of tested bezimidazoles showed remarkable antiprotozoal activity against Giardia intestinalis, Entamoeba histolytica and Trichomonas vaginalis. Of the studied collection of halogenated benzimidazoles the most anticancer-active was the 5,6-dichloro-2-pentafluoroethyl compound, particularly against breast and prostate cancer cell lines. (C) 2002 Editions scientifiques et medicales Elsevier SAS. All rights reserved.
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