期刊
IUBMB LIFE
卷 54, 期 6, 页码 323-333出版社
WILEY
DOI: 10.1080/15216540216037
关键词
myopathies; striated muscle regulation; troponin isoforms
资金
- NHLBI NIH HHS [HL42325] Funding Source: Medline
Troponin (Tn) is the sarcomeric Ca2+ regulator for striated (skeletal and cardiac) muscle contraction. On binding Ca2+ To transmits information via structural changes throughout the actin-tropomyosin filaments, activating myosin ATPase activity and muscle contraction. Although the Tn-mediated regulation of striated muscle contraction is now well understood, the role of different Tn isoforms in these processes is the subject of intensive investigations. This review addresses the physiological significance of the multiple Tn isoforms in skeletal and cardiac muscles as well as their role in the regulation of contraction.
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