期刊
JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY
卷 50, 期 6, 页码 1027-1030出版社
OXFORD UNIV PRESS
DOI: 10.1093/jac/dkf198
关键词
amphotericin B formulations; Scedosporium; polymorphonuclear leucocytes
Scedosporium prolificans and Scedosporium apiospermum are resistant to most antifungal agents and cause refractory pulmonary and disseminated infections. The combined effects of deoxycholate amphotericin B, amphotericin B lipid complex and liposomal amphotericin B with human polymorphonuclear leucocytes (PMNs) in damaging hyphae of these fungi were evaluated by XTT assay. Amphotericin B lipid complex displayed a significant additive effect with PMNs against both Scedosporium species (22% for S. prolificans and 81% for S. apiospermum; P < 0.04). None of the formulations adversely affected the PMN antifungal activity. These findings may be important in designing better strategies for management of infections due to these organisms.
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