期刊
JOURNAL OF VIROLOGY
卷 76, 期 23, 页码 12335-12343出版社
AMER SOC MICROBIOLOGY
DOI: 10.1128/JVI.76.23.12335-12343.2002
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资金
- NIAID NIH HHS [R01 AI023946] Funding Source: Medline
- NIGMS NIH HHS [R01 GM063228] Funding Source: Medline
- DRS NIH HHS [RSB-GM63228, RSB-AI23946] Funding Source: Medline
Attachment of Norwalk (NV), Snow Mountain (SMV), and Hawaii (HV) virus-like particles (VLPs) to specific ABH histo-blood group antigens was investigated by using human saliva and synthetic biotinylated carbohydrates. The three distinct Norwalk-like viruses (NLVs) have various capacities for binding ABH histo-blood group antigens, suggesting that different mechanisms for NLV attachment likely exist. Importantly, antisera from NV-infected human volunteers, as well as from mice inoculated with packaged Venezuelan equine encephalitis virus replicons expressing NV VLPs, blocked the ability of NV VLPs to bind synthetic H type 1, Le(b), and H type 3, suggesting a potential mechanism for antibody-mediated neutralization of NV.
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