Efficient routine production of the 18F-labelled amino acid O-(2-[18F]fluoroethyl)-L-tyrosine

A convenient remotely controlled no-carrier-added synthesis of enantiomerically pure O-(2-[F-18]fluoroethyl)-L-tyrosine (FET) is described. This allows the distribution of the radiotracer to other laboratories according to the satellite concept. The radiochemical yield obtained within 80 min is about 60%. The FET containing HPLC fraction can be used immediately (after adding sodium chloride) for human application. (C) 2002 Elsevier Science Ltd. All rights reserved.