期刊
JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY
卷 61, 期 12, 页码 1040-1047出版社
AMER ASSN NEUROPATHOLOGISTS INC
DOI: 10.1093/jnen/61.12.1040
关键词
argyrophilic grain disease; CA2; hippocampus; neurofibrillary tangles; tau
资金
- NIA NIH HHS [AG03949, AG17216, AG14449, AG16574] Funding Source: Medline
- NINDS NIH HHS [NS40256] Funding Source: Medline
The CA2 sector of the hippocampus is relatively resistant ton eurofibrillary tangles in aging and Alzheimer disease; however, some cases have selective neurofibrillary degeneration in CA2 with sparing of the, more vulnerable CA1 sector. Cases such as this do not fit in the Braak and Braak staging scheme and can be considered to have air atypical pattern of neurofibrillary degeneration. We identified 24, atypical cases with an average, age at death of 78.6 +/- 1.4 yr and average Braak stage of 3.2 +/- 0.4 and describe their pathologic and genetic characteristics with Gallyas silver staining, immunohistochemistry for tau and alphaB-crystallin; as well as apolipoprotein-E (ApoE) and tau genotyping. Three cases were excluded from further analysis due to presence of hippocampal sclerosis. All but 1 of the remaining 21 atypical cases were four-repeat (4R) tauopathies, including progressive supranuclear palsy; corticobasal degeneration, and argyrophilic grain disease (AGD). Remarkably; 19 of the 21 atypical cases were pure or mixed cases of AGD. The ApoE epsilon4 allele frequency was similar to normal controls; while there was a trend for an increased frequency of the extended tau H1 haplotype in atypical cases: Selective neurofibrillary degeneration in CA2 sector of the hippocampus is not widely recognized; but when detected should suggest the possibility of a 4R-tauopathy, particularly AGD.
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