期刊
JOURNAL OF NEUROPHYSIOLOGY
卷 88, 期 6, 页码 2899-2908出版社
AMER PHYSIOLOGICAL SOC
DOI: 10.1152/jn.00037.2002
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资金
- NINDS NIH HHS [NS-07395] Funding Source: Medline
- BLRD VA [I01 BX000386] Funding Source: Medline
The presence, magnitude, and time course of GABA transporter currents were investigated in electrophysiologically characterized neocortical astrocytes in an in vitro slice preparation. On stimulation with a bipolar-tungsten stimulating electrode placed nearby, the majority of cells tested displayed long-lasting GABA transporter currents using both single and repetitive stimulation protocols. Using subtype-specific GABA transporter antagonists, long-lasting GABA transporter cur-rents were identified in neocortical astrocytes that originated from at least two subtypes of GABA transporters: GAT-1 and GAT-2/3. These transporter currents displayed slow rise times and long decay times, contrasting the time course observed for glutamate transporter currents, and are indicative of a long extracellular time course of GABA as well as a role for glial GABA transporters during synaptic transmission.
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