期刊
EUROPEAN JOURNAL OF CLINICAL INVESTIGATION
卷 32, 期 12, 页码 938-942出版社
BLACKWELL PUBLISHING LTD
DOI: 10.1046/j.1365-2362.2002.01075.x
关键词
fat mass; gender; genotype; hormone-sensitive lipase; obesity; polymorphism
Background The hormone sensitive lipase (HSL) catalyses the breakdown of adipose tissue triglycerides into free fatty acids. The objective of this study was to determine whether HSLi6 microsatellite allele 5 (A5) and/or homozygosity for this allele is associated with body fat in Swedes. Design A large case-control study on gender-specific association for several body fat-related clinical parameters to HSLi6 A5, and to HSLi6 A5 homozygosity, comparing A5 with the other alleles in group. The subjects were 323 obese patients (85 males, 238 females) without other metabolic complication, and 301 nonobese healthy individuals (134 males, 167 females). They were analyzed for various body fat-related clinical parameters, and HSLi6 genotype. Results Homozygosity for HSLi6 A5 was a risk factor for obesity, BMI greater than or equal to 30 kg m(-2) (Odds ratio = 1.75, 95% CI 1.58-1.93) and body fat mass > 39.6% (Odds ratio = 1.89,95% CI 1.60-2.23) in women. This genotype was also associated with increased diastolic blood pressure and triglyceride level among nonobese women, and with increased body fat mass and waist/ hip ratio among nonobese men. Conclusion HSLi6 A5 homozygosity is a risk factor for body fat accumulation.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据