期刊
AMERICAN JOURNAL OF HUMAN GENETICS
卷 71, 期 6, 页码 1330-1341出版社
CELL PRESS
DOI: 10.1086/344696
关键词
-
资金
- NHLBI NIH HHS [P01 HL67664, T32 HL007427, N01 HLC6795, N01HR16049, N01 HR16049, P01 HL067664, N01HR16044, T32 HL07427] Funding Source: Medline
- PHS HHS [R01 NL66386] Funding Source: Medline
In the present article, we address family-based association tests (FBATs) for quantitative traits. We propose an approach to analytical power and sample-size calculations for general FBATs; this approach can be applied to virtually any scenario (missing parental information, multiple offspring per family, etc.). The power calculations are used to discuss optimal choices of the phenotypes for the FBAT statistic and its power's dependence on ascertainment conditions, on study design, and on the correct specification of the distributional assumptions for the phenotypes. We also compare the general FBAT approach with PDT and QTDT. The practical relevance of our theoretical considerations is illustrated by their application to an asthma study.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据