期刊
PSYCHIATRIC GENETICS
卷 12, 期 4, 页码 193-206出版社
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1097/00041444-200212000-00002
关键词
CD/DVD discs; genotyping; gene variants; MEMS; microarrays; nanotechnology; neurogenomics; neurologic disorders; optical discs; pathogen detection; pharmacogenomics
The role of genotypic analysis in disease diagnostics and drug response assessment is continually expanding. New genomic discoveries combined with new, novel technologies may provide a greater range of testing capabilities in the near future. We describe the application of nanotechnology, in which DNA microarrays have been placed in a microchannel environment that can be read and analyzed in an optical (CD/DVD) disc drive system. The potential exists to combine molecular and immunological applications together into a rapid, low-cost, high-capacity screening platform. The relevance of this technology is discussed in respect to infectious agent detection, pharmacogenomics, neurogenomics and genetic variations associated with neurologic diseases. (C) 2002 Lippincott Williams Wilkins.
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