期刊
CURRENT OPINION IN BIOTECHNOLOGY
卷 13, 期 6, 页码 572-577出版社
ELSEVIER SCI LTD
DOI: 10.1016/S0958-1669(02)00345-2
关键词
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Historically, biotechnology has missed up to 99% of existing microbial resources by using traditional screening techniques. Strategies of directly cloning 'environmental DNA' comprising the genetic blueprints of entire microbial consortia (the so-called 'metagenome') provide molecular sequence space that along with ingenious in vitro evolution technologies will act synergistically to bring a maximum of available sequence-space into biocatalytic application.
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