期刊
JOURNAL OF INFECTIOUS DISEASES
卷 186, 期 -, 页码 S145-S151出版社
OXFORD UNIV PRESS INC
DOI: 10.1086/344264
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资金
- NINDS NIH HHS [R21 NS048866] Funding Source: Medline
The central nervous system (CNS) is considered an immunoprivileged site with restricted access and a unique microenvironment that profoundly affects the capacity of T cells to exert their functions. The lymphocytic choriomeningitis virus model offers a unique system in which to evaluate the contrasting roles of specific T cells in causing lethal CNS disease or curing pervasive and life-long CNS infection. Specific T cell kinetics in the periphery is briefly discussed. The T cell-mediated mechanisms leading to fatal choriomeningitis are reviewed as are recent methodologic advances that will facilitate the study of antigen-specific T cells in disease pathogenesis. Understanding the specific constraints imposed by the CNS on local T cell activity has important consequences for the design of therapeutic strategies aimed at preventing or curing CNS infection.
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