期刊
CURRENT OPINION IN CHEMICAL BIOLOGY
卷 6, 期 6, 页码 823-828出版社
CURRENT BIOLOGY LTD
DOI: 10.1016/S1367-5931(02)00394-0
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资金
- NIGMS NIH HHS [GM49243] Funding Source: Medline
Less than a decade old, single-molecule fluorescence of nucleic acids has rapidly become an important tool in the arsenal of biological probes. A variety of novel approaches to investigate conformational dynamics, catalytic mechanisms, folding pathways and protein-nucleic-acid interactions have recently been devised for nucleic acids using this technique. Combined with biomechanical tools and ensemble measurements, single-molecule fluorescence methods extend our ability to observe and understand biomolecules and complex biological processes.
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