期刊
TRENDS IN CELL BIOLOGY
卷 12, 期 12, 页码 562-569出版社
ELSEVIER SCIENCE LONDON
DOI: 10.1016/S0962-8924(02)02405-4
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Signaling pathways that play a fundamental role during development are turning out to underlie many disease states when misregulated. Here, we review some of the recent findings in the Hedgehog (Hh) pathway and the role it plays in different human diseases. We present a summary of the diseases that result from the inactivation or inappropriate activation of the Hh pathway. The human phenotypes generally fit the findings in model organisms and help to identify some potential targets for therapy.
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