期刊
CURRENT OPINION IN CHEMICAL BIOLOGY
卷 6, 期 6, 页码 872-877出版社
CURRENT BIOLOGY LTD
DOI: 10.1016/S1367-5931(02)00385-X
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资金
- NIAID NIH HHS [R01 AI072666] Funding Source: Medline
- NIGMS NIH HHS [5 T32 GM08382-10] Funding Source: Medline
Non-natural, sequence-specific peptidomimetic oligomers are being designed to mimic bioactive peptides, with potential therapeutic application. Cationic, facially amphipathic helical beta-peptide oligomers have been developed as magainin mimetics. Non-natural mimics of HIV-Tat protein, lung surfactant proteins, collagen, and somatostatin are also being developed. Pseudo-tertiary structure in beta-peptides and peptoids may herald the creation of entirely artificial proteins.
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