期刊
RADIOTHERAPY AND ONCOLOGY
卷 65, 期 3, 页码 145-151出版社
ELSEVIER IRELAND LTD
DOI: 10.1016/S0167-8140(02)00307-9
关键词
prostate neoplasms; neoplasms; second primary; radiotherapy; registries
Background and purpose: To describe the risk of second malignancy following a diagnosis of prostate cancer, in British Columbia (BC), Canada. To ascertain whether that risk changed with the use of radiation therapy. Methods and materials: All invasive cases of prostate cancer diagnosed from 1984 through to 2000 were retrieved from the BC Tumor Registry. Standardized incidence ratios (SIRs) were calculated from observed and expected numbers as a percentage. Patients were divided into those who received high-dose radiation therapy (greater than or equal to45 Gy, RT group) and those not treated with radiation (non-RT group). Results: Overall there was no significant difference between observed and expected second cancer rates, SIR = 100 (RT group, N = 101; non-RT group, N = 98, P = n.s.). Individual tumour sites at significantly increased risk (P <0.01) included bladder (non-RT group, SIR = 132), colo-rectal (RT group, SIR = 121), pleura (RT group, SIR = 228). Other sites of possible significance (P < 0.05) include sarcoma (RT group, SIR = 170) and testis (non-RT group, SIR = 282). Conclusions: Increased rates of bladder and testis cancers in the non-RT group are likely to be due to increased urologist surveillance and the use of therapeutic orchiectomy. Increased rates of colorectal cancer in those treated with radiation may be either due to surveillance or treatment. Increases in sarcomas in the RT group are probably treatment-related. Overall the increased second cancer risk for those undergoing radiation therapy was 1 in 220. (C) 2002 Elsevier Science Ireland Ltd. All rights reserved.
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