期刊
BIOMATERIALS
卷 23, 期 24, 页码 4915-4921出版社
ELSEVIER SCI LTD
DOI: 10.1016/S0142-9612(02)00251-X
关键词
poly(epsilon-caprolactone); silica; hybrid; bioactivity; biodegradability
A bioactive and degradable poly(epsilon-caprolactone)/silica hybrid was synthesized for the application as a bone substitute. Triethoxysilane end capped poly(epsilon-caprolactone) was prepared by the reaction with alpha,omega-hydroxyl poly(epsilon-caprolactone) and 3-isocyanatopropyl triethoxysilane using 1,4-diazabicyclo[2,2,2,]octane as a catalyst. It was then co-condensed with tetraethyl orthosilicate and calcium nitrate tetrahydrate via a sol-gel method. The bioactivity of the poly(epsilon-caprolactone)/silica hybrid was assessed using simulated body fluid and low crystalline apatite was successfully formed on its surface after soaking for I week at 36.5degreesC. Its biodegradability was evaluated in the phosphate buffered saline and the degradability was mostly come from the poly(epsilon -caprolactone) phase in the hybrid. It means that this hybrid is likely to be applicable to a bioactive and degradable bone substitute. (C) 2002 Elsevier Science Ltd. All rights reserved.
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