期刊
ELECTROANALYSIS
卷 14, 期 24, 页码 1699-1706出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/elan.200290013
关键词
anti-inflammatory drugs; differential pulse voltammetry; overlapped signals; partial least squares; accuracy
An application of a partial least squares calibration method for the simultaneous voltammetric determination of indomethacin, acemethacin, piroxicam and tenoxicam is suggested. It was shown that it is possible to resolve complex mixtures of analytes even when they have strongly overlapped signals. In order to check the proposed method, statistical analysis of the results was performed by mean of hypothesis tests. The method developed was applied to the electrochemical reduction region of four anti-inflammatory drugs and allowed the drugs to be quantified at concentrations between 0.52 and 4.09 mug mL(-1) for acemethacin, 0.44 and 3.50 mug mL(-1) for indomethacin, 0.43 and 3.40 mug mL(-1) for piroxicam, and 0.42 and 3.30 mug mL(-1) for tenoxicam with good results. The average absolute value of relative errors was 2.25%, 4.31%, 1.68% and 2.49%, respectively.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据