Neuropeptide Y and its receptors as potential therapeutic drug targets

Neuropeptide Y (NPY) is a 36-amino-acid peptide that exhibits a large number of physiological activities in the central and peripheral nervous systems. NPY mediates its effects through the activation of six G-protein-coupled receptor subtypes named Y-1, Y-2, Y-3, Y-4, Y-5, and Y-6. Evidence suggests that NPY is involved in the pathophysiology of several disorders, such as the control of food intake, metabolic 'disorders, anxiety, seizures, memory, circadian rhythm, drug addiction, pain, cardiovascular diseases, rhinitis, and endothelial cell dysfunctions. The synthesis of agonists and antagonists for these receptors could be useful to treat several of these diseases. (C) 2002 Elsevier Science B.V. All rights reserved.