期刊
MECHANISMS OF DEVELOPMENT
卷 119, 期 2, 页码 191-200出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/S0925-4773(02)00361-1
关键词
Xhex; anterior patterning; Xenopus; endoderm
Two regions expressing Hex in the early gastrula contribute to organizing the anterior of the vertebrate embryo. In Xenopus, these include the anterior yolky endoderm and the suprablastoporal endoderm (SBE), which is fated to form the epithelial lining of the gut. These tissues may correspond to the anterior visceral endoderm and anterior definitive endoderm of amniotes. Genetic studies in mice have demonstrated the important roles of these tissues in producing anterior identity in the adjacent neural ectoderm. In Xenopus, both the anterior endoderm and the SBE have anterior inducing properties; furthermore, the SBE can organize a full anterior-posterior axis. Inhibition of Xhex function shows that both these Xhex-expressing endodermal tissues are required for anterior development in Xenopus. (C) 2002 Elsevier Science Ireland Ltd. All rights reserved.
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