期刊
PEPTIDES
卷 23, 期 12, 页码 2213-2221出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/S0196-9781(02)00252-8
关键词
MCH; hippocampus; nitric oxide; cGMP; synaptic transmission; behavior
The Present study. attempts to determine, if the effect of melanin-concentrating hormone (MCH) upon memory retention is correlated with changes in nitric oxide synthase (NOS) activity and tissue levels of nitric oxide (NO) and cGMP. We used a behavioral experiment using a step-down inhibitory avoidance test, the biochemical determinations of NO and cGMP, and electrophysiological model. Results of behavioral studies (step-down test) showed that MCH administration reverts the amnesic effects induced by N-G-nitro-L-arginine (L-NOArg). Moreover, electrophysiological studies demonstrated that L-NOArg did not block the potentiation induced by the peptide. Hippocampal NO and cGMP levels increased after M,CH injection. (C) 2002 Elsevier Science Inc. All rights reserved.
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