期刊
BIOSTATISTICS
卷 3, 期 4, 页码 445-457出版社
OXFORD UNIV PRESS
DOI: 10.1093/biostatistics/3.4.445
关键词
bias in DerSimonian-Laird estimator; estimator of heterogeneity variance; meta-analysis; pooled analysis; population averaged study-specific weights; study-specific weights
In this paper we consider estimating heterogeneity variance with the DerSimonian-Laird (DSL) estimator as typically used in meta-analysis. In its general form the DSL estimator requires inverse population-averaged study-specific variances as weights, in which case the estimator is unbiased. It has become common practice, however, to use estimates of the study-specific variances instead of their population-averaged versions. This can lead to considerable bias. Simulations illustrate these findings.
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