期刊
JOURNAL OF NEURAL TRANSMISSION
卷 109, 期 12, 页码 1499-1504出版社
SPRINGER WIEN
DOI: 10.1007/s007020200097
关键词
glaucoma; homocysteine; MTHFR polymorphism; glaucomatous optic neuropathy
Homocysteine levels and the frequency of heterozygous methylenetetrahydrofolate reductase (MTHFR) C677T mutation are increased in open-angle glaucoma. Since homocysteine can induce vascular injury, alterations in extracellular matrix remodelling, and neuronal cell death, these findings may have important implications for understanding glaucomatous optic neuropathy.
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