期刊
NATURE IMMUNOLOGY
卷 3, 期 12, 页码 1163-1168出版社
NATURE AMERICA INC
DOI: 10.1038/ni851
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- NIAID NIH HHS [R37AI29873] Funding Source: Medline
- NIAMS NIH HHS [R21AR48037, K08AR01996, K08AR02171] Funding Source: Medline
Both microbial products and T cell factors influence dendritic cell (DC) maturation. However, it is not known which T cells are capable of interacting with DCs at the initiation of adaptive immunity, when foreign antigen-specific T cells are rare. We show here that self-reactive CD1-restricted T cells can promote DC maturation by recognizing CD1 in the absence of foreign antigens. T cell recognition of all four CD1 isoforms can trigger DC maturation, but their distinct mechanisms of costimulation lead to profound differences in concomitant interleukin 12 p70 production. Distinct CD1-reactive T cells may thus differentially direct DC development early in the immune response, thereby controlling subsequent polarization of acquired immunity.
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