期刊
CANCER LETTERS
卷 186, 期 1, 页码 11-18出版社
ELSEVIER IRELAND LTD
DOI: 10.1016/S0304-3835(01)00811-4
关键词
genistein; chemoprevention; rat; prostate; cancer
类别
资金
- NCI NIH HHS [P30-CA13148-26] Funding Source: Medline
- NCRR NIH HHS [S10RR06487] Funding Source: Medline
Epidemiological reports suggest that Asians consuming a diet high in soy have a low incidence of clinically manifested prostate cancer. We have tested the hypothesis that life-time exposure to genistein, the primary isoflavone component of soy, is responsible for this protective effect. Lobund-Wistar rats were exposed to 0, 25 and 250 mg genistein/kg AIN-76A diet, starting at conception and continued until necropsy at I I months. Male offspring were injected s.c. with Flutamide on days 50-66 and with testosterone on days 67-69, injected with N-methylnitrosourea (NMU) into the dorsal prostate on day 70, and given testosterone implants, starting at day 77. Genistein in the diet inhibited the development of NMU-induced prostate invasive adenocarcinomas, in a dose-dependent manner. Genistein did not alter body, prostate and testes weights. Male rats fed 0, 25 and 250 mg genistein/kg diet had serum genistein concentrations of 9, 60 and 861 pmol/ml, and prostate genistein concentrations of 85, 230 and 775 pmol/g tissue. We conclude that lifetime dietary genistein protected against chemically induced prostate cancer development in rats. (C) 2002 Elsevier Science Ireland Ltd. All rights reserved.
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