期刊
JOURNAL OF CELL SCIENCE
卷 115, 期 23, 页码 4447-4455出版社
COMPANY OF BIOLOGISTS LTD
DOI: 10.1242/jcs.00139
关键词
Golgi; SNARE; syntaxin; membrane fusion; Drosophila
类别
资金
- Canadian Institutes of Health Research [42394] Funding Source: Medline
SNARE isoforms appear to regulate specific intracellular membrane trafficking steps. To identify new SNARE proteins in Drosophila melanogaster we used a yeast two-hybrid screen to search for proteins that interact with SNAP. Here we report the identification of the Drosophilia homologue of syntaxin 16. dsyntaxin 16 binds SNAP in a concentration-dependent fashion and genetically interacts with NSF2. Like its mammalian homologue, dsyntaxin 16 is ubiquitously expressed and appears to be localized to the Golgi apparatus. In addition, membranes containing dsyntaxin 16 become aggregated upon Brefeldin A treatment and are dispersed during meiosis. Inhibition of dsyntaxin 16 function by overexpression of truncated forms in cultured Schneider cells indicates that dsyntaxin 16 may selectively regulate Golgi dynamics.
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