期刊
BIOTECHNOLOGY ADVANCES
卷 20, 期 5-6, 页码 321-339出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/S0734-9750(02)00026-5
关键词
chemical complementarity; structural compatibility; hydrophobic interactions; molecular engineering; nanostructures; biological scaffold
Understanding of new materials at the molecular level has become increasingly critical for a new generation of nanomaterials for nanotechnology, namely, the design, synthesis and fabrication of nanodevices at the molecular scale. New technology through molecular self-assembly as a fabrication tool will become tremendously important in the coming decades. Basic engineering principles for microfabrication can be learned by understanding the molecular self-assembly phenomena. Self-assembly phenomenon is ubiquitous in nature. The key elements in molecular self-assembly are chemical complementarity and structural compatibility through noncovalent interactions. We have defined the path to understand these principles. Numerous self-assembling systems have been developed ranging from models to the study of protein folding and protein conformational diseases, to molecular electronics, surface engineering, and nanotechnology, Several distinctive types of self-assembling peptide systems have been developed. Type I, molecular Lego forms a hydrogel scaffold for tissue engineering; Type II, molecular switch as a molecular actuator; Type III, molecular hook and molecular velcro for surface engineering; Type IV, peptide nanotubes and nanovesicles, or molecular capsule for protein and gene deliveries and Type V, molecular cavity for biomineralization. These self-assembling peptide systems are simple, versatile and easy to produce. These self-assembly systems represent a significant advance in the molecular engineering for diverse technological innovations. (C) 2002 Elsevier Science Inc. All rights reserved.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据