期刊
NEURON
卷 36, 期 5, 页码 855-868出版社
CELL PRESS
DOI: 10.1016/S0896-6273(02)01067-X
关键词
-
资金
- NICHD NIH HHS [Z01 HD000713-11] Funding Source: Medline
Neuronal activity influences myelination of the brain, but the molecular mechanisms involved are largely unknown. Here, we report that oligodendrocyte progenitor cells (OPCs) express functional adenosine receptors, which are activated in response to action potential firing. Adenosine acts as a potent neuronglial transmitter to inhibit OPC proliferation, stimulate differentiation, and promote the formation of myelin. This neuron-glial signal provides a molecular mechanism for promoting oligodendrocyte development and myelination in response to impulse activity and may help resolve controversy on the opposite effects of impulse activity on myelination in the central and peripheral nervous systems.
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