期刊
AIDS
卷 16, 期 18, 页码 2489-2491出版社
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1097/00002030-200212060-00020
关键词
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Eighteen patients with HIV lipoatrophy, receiving quadruple reverse transcriptase-inhibitor therapy including stavudine or zidovudine, were randomly assigned to continue current therapy or stop stavudine/zidovudine. After 24 weeks more limb fat had recovered in the stop than in the continue group; however, five of the stop subjects experienced virological failure. The withdrawal of thymidine analogues from a protease inhibitor-sparing regimen can improve peripheral fat, but compromises virological control.
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