期刊
SCIENCE
卷 298, 期 5600, 页码 1942-1946出版社
AMER ASSOC ADVANCEMENT SCIENCE
DOI: 10.1126/science.1072163
关键词
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资金
- NIGMS NIH HHS [GM51426, GM18568, GM32506] Funding Source: Medline
Bacteria are often highly polarized, exhibiting specialized structures at or near the ends of the cell. Among such structures are actin-organizing centers, which mediate the movement of certain pathogenic bacteria within the cytoplasm of an animal host cell; organized arrays of membrane receptors, which govern chemosensory behavior in swimming bacteria; and asymmetrically positioned septa, which generate specialized progeny in differentiating bacteria. This polarization is orchestrated by complex and dynamic changes in the subcellular localization of signal transduction and cytoskeleton proteins as well as of specific regions of the chromosome. Recent work has provided information on how dynamic subcellular localization occurs and how it is exploited by the bacterial cell.
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