期刊
ADVANCED DRUG DELIVERY REVIEWS
卷 54, 期 12, 页码 1539-1551出版社
ELSEVIER
DOI: 10.1016/S0169-409X(02)00149-7
关键词
dementia; neurodegeneration; A beta; paired helical filaments; fibrillogenesis; familial Alzheimer's disease; A beta PP
资金
- NIA NIH HHS [AG05891, AG08721, AG10491] Funding Source: Medline
- NINDS NIH HHS [NS38777] Funding Source: Medline
Alzheimer's disease (AD) is the most frequent type of amyloidosis in humans and the commonest form of dementia. Extracellular Abeta amyloid deposits in the form of amyloid plaques and cerebral amyloid angiopathy as well as intraneuronal neurofibrillary tangles co-exist in the brain parenchyma of AD patients, the cognitive areas being the most severely affected. This review focuses on the potential role of amyloid in the development of neurodegeneration and presents studies of AD and other unrelated inherited dementia syndromes associated with neuronal loss and amyloid deposition in the brain. (C) 2002 Elsevier Science B.V. All rights reserved.
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