期刊
JOURNAL OF COMPARATIVE NEUROLOGY
卷 454, 期 2, 页码 105-114出版社
WILEY-LISS
DOI: 10.1002/cne.10417
关键词
nearogenesis; PSA-NCAM; immunocytochemistry; soma
资金
- NIA NIH HHS [AG15072] Funding Source: Medline
- NIMH NIH HHS [MH39327] Funding Source: Medline
- NINDS NIH HHS [R29 NS35941] Funding Source: Medline
We have examined the distribution of synapsin III in the adult mouse brain. Expression of synapsin III was observed in puncta throughout the brain, but demonstrated greater regional variation than that of synapsins I or II. This punctate staining is typical for synaptic vesicle proteins located at nerve terminals. These findings are also consistent with the well-established role for synapsins in regulating neurotransmitter release. However, unexpectedly, synapsin III was also highly expressed in the cell body and processes of immature neurons in neurogenic regions of the adult brain, such as the hippocampal dentate gyrus, rostral migratory stream, and olfactory bulb. Many synapsin III-positive neurons also reacted with an antibody directed toward polysialylated-neuronal cell adhesion molecule, a marker of immature, migrating neurons. These results suggest that synapsin III may also play a role in adult neurogenesis.
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