期刊
CANCER LETTERS
卷 187, 期 1-2, 页码 153-162出版社
ELSEVIER SCI IRELAND LTD
DOI: 10.1016/S0304-3835(02)00402-0
关键词
5-fluorouracil; Apcm(Min/+) mouse; folic acid; tumor recovery
类别
资金
- NCI NIH HHS [CA 76560, CA 78651] Funding Source: Medline
5-Fluorouracil (5-FU) has been the foundation of advanced colorectal cancer treatment for over 40 years. The Apc(Min/+) mouse, which is genetically predisposed to intestinal neoplasia, was used to examine the effects of 5-FU in this system and the impact of dietary folic acid on those effects. 5-FU treatment resulted in a 60-80% reduction in tumor number. Clinically relevant toxicities, including myelosuppression and mucositis, are a part of this response. Tumor numbers rebounded completely following termination of 5-FU therapy, indicating that the drug inhibits tumor growth but does not eradicate them. In mice that were fed with a defined diet containing no folic acid (0 ppm), 5-FU not only induced regression of pre-existing tumors, but also inhibited tumor recovery following drug withdrawal. Our data indicate that a dietary folic acid deficiency, in promoting tumor regression and inhibiting tumor recovery, may enhance the therapeutic effects of 5-FU. (C) 2002 Elsevier Science Ireland Ltd. All rights reserved.
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