期刊
SCIENCE
卷 298, 期 5601, 页码 2211-2213出版社
AMER ASSOC ADVANCEMENT SCIENCE
DOI: 10.1126/science.1076701
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资金
- NHLBI NIH HHS [HL64148] Funding Source: Medline
- NIDA NIH HHS [DA13349] Funding Source: Medline
- NIMH NIH HHS [MH60385] Funding Source: Medline
Melanopsin has been proposed as an important photoreceptive molecule for the mammalian circadian system. Its importance in this role was tested in melanopsin knockout mice. These mice entrained to a light/dark cycle, phase-shifted after a light pulse, and increased circadian period when light intensity increased. Induction of the immediate-early gene c-fos was observed after a nighttime light pulse in both wild-type and knockout mice. However, the magnitude of these behavioral responses in knockout mice was 40% lower than in wild-type mice. Although melanopsin is not essential for the circadian clock to receive photic input, it contributes significantly to the magnitude of photic responses.
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