期刊
BIOCHEMICAL JOURNAL
卷 368, 期 -, 页码 679-682出版社
PORTLAND PRESS
DOI: 10.1042/BJ20021413
关键词
ACBP; acyl-CoA esters; lipid metabolism; small interference RNA (siRNA)
In the present work, small interference RNA was used to knock-down acyl-CoA binding protein (ACBP) in HeLa, HepG2 and Chang cells. Transfection with ACBP-specific siRNA stopped growth, detached cells from the growth surface and blocked thymidine and acetate incorporation. The results show that depletion of ACBP in mammalian cells results in lethality, suggesting that ACBP is an essential protein.
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