期刊
CANCER LETTERS
卷 188, 期 1-2, 页码 153-162出版社
ELSEVIER IRELAND LTD
DOI: 10.1016/S0304-3835(02)00455-X
关键词
Myc; Max; Mad; heterodimer; E-box; unsaturated fatty acids; SNU16 cells; gene regulation; tumorigenesis; gene expression; linoleic acid; proliferation
类别
Oncoprotein Myc, hetero-dimerized with Max through a b/HLH/Zip region, is a transcription factor that governs important cellular processes such as cell cycle entry, proliferation and differentiation. We found that linoleic acid, isolated from Pollen Typhae, and other unsaturated fatty acids have strong inhibitory effects on the binding of Myc-Max heterodimer to an E-box DNA site (CA(C/T)GTG). The interaction of a fatty acid with a protein dimer, not with DNA, is assumed to block the entire Myc-Max-DNA complex formation. Unsaturated fatty acids also showed cytotoxicity against a SNU16 human stomach cancer cell line and conjugated linoleic acid suppressed mRNA expression of several myc-target genes; ornithine decarboxylase, p53, cdc25a in the SNU16 cells. (C) 2002 Elsevier Science Ireland Ltd. All rights reserved.
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