期刊
DEVELOPMENTAL BRAIN RESEARCH
卷 139, 期 2, 页码 151-158出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/S0165-3806(02)00541-2
关键词
brain sexual differentiation; hypothalamus; glia; gonadal steroid; GFAP; estradiol; testosterone
The arcuate nucleus of the hypothalamus is one of several sexually dimorphic hypothalamic nuclei. We have previously demonstrated that astrocytes in the neonatal arcuate nucleus exhibit a marked sexually dimorphic morphology as a result of differential exposure to gonadal steroids by postnatal day (PN) 2, with males having complex stellate cells compared to the simple bipolar ones found in females. Here, we present data demonstrating that arcuate astrocytes are sexually dimorphic by the day of birth and continue as such throughout postnatal development (PN0-PN15), and persist into adulthood. These data suggest that early gonadal steroid exposure permanently organizes arcuate astrocyte morphology. The male versus female difference in astrocyte morphology may contribute to the sexually dimorphic regulation of neuroendrocrine secretions from the pituitary in the adult. (C) 2002 Elsevier Science B.V. All rights reserved.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据