期刊
ANAIS DA ACADEMIA BRASILEIRA DE CIENCIAS
卷 87, 期 2, 页码 1113-1123出版社
ACAD BRASILEIRA DE CIENCIAS
DOI: 10.1590/0001-3765201520140370
关键词
biological activity; marine invertebrate; natural product; Sphenopidae
资金
- Conselho Nacional de Desenvolvimento Cientifico e Tecnologico (CNPq)
- Fundacao Cearense de Apoio ao Desenvolvimento Cientifico e Tecnologico (FUNCAP)
- Coordenacao de Aperfeicoamento de Pessoal de Nivel Superior (CAPES) of the Brazilian Government
Marine invertebrates are capable of synthesizing bioactive compounds, which may be beneficial to human health. The aim of this study was to evaluate the antioxidant, hemolytic, antimicrobial and cytotoxic activities of crude extract (70% EtOH), and dichloromethane (DCM), ethyl acetate (EtOAc), and aqueous (Aq) fractions of the marine zoanthid Palythoa caribaeorum. The phenolic compound contents of the crude extract, DCM, EtOAc and Aq fractions were 12.33, 18.17, 10.53, and 3.18 mg GAE per gram, respectively. DPPH radical scavenging activity showed slight variation. IC50 of crude extract, DCM, EtOAc and Aq fractions were 11.13, 11.25, 11.74, and 11.28 mu g mL(-1), respectively. Among the sample, ferrous ion chelating was the highest in crude extract (IC50 302.90 mu g mL(-1)), followed by EtOAc, Aq, and DCM fractions with 457.77, 547.91, and 641.82 mu g mL(-1), respectively. Ferric-reducing antioxidant power showed optical density at about 0.5. The samples tested exhibited low hemolytic activity under 10% up to a concentration of 50 mu g mL(-1). No antimicrobial activity was observed against any of the tested bacterial strains. For the cytotoxic activity, LC50 of DCM, crude extract, EtOAc, and Aq were 52.10, 83.06, 86.34, and 117.45 mu g mL(-1), showing high toxicity.
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