期刊
DEVELOPMENTAL BRAIN RESEARCH
卷 139, 期 2, 页码 199-203出版社
ELSEVIER
DOI: 10.1016/S0165-3806(02)00550-3
关键词
glucocorticoid receptor; serotonin; serotonin-7 receptor; cAMP; hippocampus
Glucocorticoid receptor expression in primary hippocampal cell cultures was significantly increased with either 10 mM 8-bromo cAMP, 50 nM 5-carboxamidotryptamine (5-CT), a potent 5-HT7 receptor agonist, or 100 nM 5-HT. The effect of 5-HT or 5-CT was blocked with methiothepin or by a protein kinase A inhibitor, but not pindolol. These results suggest that the effects of 5-HT on hippocampal GR expression is mediated by a 5-HT7 receptor. (C) 2002 Elsevier Science B.V. All rights reserved.
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