Changes in cognitive functioning following comprehensive treatment for first episode patients with schizophrenia spectrum disorders

The course of cognitive functioning over a 1-year period,vas examined among a community cohort of individuals presenting with first episode schizophrenia spectrum psychosis. Data were obtained for 83 outpatients at entry to an early intervention program and 12 months later on the National Adult Reading Test. Wechsler Adult Intelligence Scales-Third Edition, Wechsler Memory Scales-Third Edition. Paced Auditory Serial Addition Task. Wisconsin Card Sorting Test, Stroop Colour and Word Test, Trail Making Test, Continuous Performance Task, and Thurstone Word Fluency Test. Paired sample t-tests indicated significant and positive changes in verbal and non-verbal intelligence, auditory and visual memory, working memory and some aspects of executive functioning. Processing speed also improved though remained an area of relative weakness for this sample. Findings indicated generally average performance at both assessment periods. Neither gender nor duration of untreated psychosis were related to the degree of change in cognitive functioning for this sample. The implications of these findings and the impact of early intervention with this population are discussed, (C) 2002 Elsevier Science Ireland Ltd. All rights reserved.