期刊
VACCINE
卷 20, 期 -, 页码 A46-A51出版社
ELSEVIER SCI LTD
DOI: 10.1016/S0264-410X(02)00387-0
关键词
recent thymic emigrants; apoptosis assays; TREC; CD8(+) T lymphocytes
Rapid turnover of lymphocytes observed in patients with cancer appears to be driven by increased apoptosis of T lymphocytes or insufficient thymic output of recent thymic emigrants (RTE). Using multicolor flow cytometry and apoptosis assays, we found that CD8(+)CD95(+)Annexin(+) T cells are dying at a rate that is significantly higher in patients with cancer than in normal controls (NC). CD8(+) effector subsets of T cells were particularly vulnerable to apoptosis. Thymic excision circle (TREC) analysis of peripheral blood lymphocytes showed a decreased number of RTE in these patients. Together, the data suggest that a high rate of T-cell turnover might contribute to immunologic imbalance in patients with cancer and have unfavorable effects on immunotherapy, including therapeutic antitumor vaccines. (C) 2002 Elsevier Science Ltd. All rights reserved.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据