期刊
JOURNAL OF MEDICINAL CHEMISTRY
卷 45, 期 26, 页码 5624-5627出版社
AMER CHEMICAL SOC
DOI: 10.1021/jm025554m
关键词
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To understand the binding of both viral and human DNA to HIV-1 integrase, fully flexible dinucleatides were docked onto the core domain of integrase. AutoDocking did identify sites on integrase where favorable interactions with nucleotides can occur, and those sites were in agreement with recently published protein fingerprinting data. By analyzing the phosphates of the docked dinucleotides, we developed a model indicating where the viral cDNA and human DNA bind to the integrase core domain.
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