Tumor-derived exosomes:: a new source of tumor rejection antigens

Exosomes are small vesicles released by a broad array of hematopoietic cells. Previous studies showed that exosomes released by antigen loaded dendritic cells induce immune-mediated anti-tumor response in mice. Here, we will describe the biochemical properties of tumor-derived exosomes and, their pre-clinical activity as cancer vaccines. (C) 2002 Elsevier Science Ltd. All rights reserved.